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Before we get started, some exciting news: I’m teaming up with my colleague Isabel Berwick — who writes the Working It newsletter, and hosts the Working It podcast — to answer more of your work and career dilemmas.

Maybe you’ve been overlooked at work? Maybe you need advice on a tricky team member? Maybe a bad manager’s got you down?

We would love to hear from you. If you have a problem you want us to help solve, you can use this link to submit it in audio. We may play your audio in the show — but you don’t need to give us your name, or where you work.

Isabel and I will answer your thorniest questions on her podcast. Please do submit your questions — we’re here to help.

The next problem

I’m 20 years old and entering my second year of university, but have recently been diagnosed with MS. I’ve worked since I was 13 and started my own business at 16, which grew quite well. But because of university and health conditions I decided to close the business down.

I want to continue with start-ups outside university and know that despite having grown my own business and having amazing mentorship I’ll need to start at the bottom. I’ve been working for a beer brand, which is the area I’d love to go into. Is it sensible or even feasible to work in start-ups — and especially alcohol start-ups — with MS?

I know big corporates like Diageo will have better processes around the illness but I don’t want to let it affect my dream or ability to make a positive impact. What is the best route for me? Male, 20s

Jonathan’s answer will be published on Monday October 2.

Jonathan Black is director of the Careers Service at the University of Oxford. Every fortnight he answers your questions on personal and career development and working life. Do you have a question for him? Email: dear.jonathan@ft.com