Bayer faces a payout of $1.56 billion after a Missouri jury found in favor of three people who blamed its popular Roundup weedkiller for causing their cancers.

The ruling is the fourth in a row to go against Bayer during a roller-coaster five-year legal battle over Roundup, the world’s most popular weedkiller, that included nine straight victories for the company, as well as earlier losses. The cases represent tens of thousands of claims from farmers and gardeners.